Hey everyone. little new here. but i would have to say that if i wanted an all around big game or general hunting cartridge i would want the 30-06. you can use the mid-weight (125,150 and 165)stuff for deer and elk and such. but then you can load it down to the accelerator(55) and hunt yotes and varmits. then you can use the 220 on moose and anything else in north america and a good bit everywhere else.