Despite the short barrel, I used RL25 in my Model 70 Featherweight with very good results. I was able to comfortably exceed the factory ballistics and got MOA with the 130 Swift Scirocco. One of my hunting buddies used RL22 with good success with the 140 Accubond as well. I know both of these powders are quite a bit slower than 4350, but the .270 WSM case is considerably more overbore than the ..270 Winchester as well . . .