Recommend a very tight fitting sabot like the barnes expander. I like 250gr for deer. I have got great luck with 3-777 pellets and that sabot, and a 209 winchester primer.

My old standby load of 95gr of pyrodex and 240gr .45" XTP mag works real well too.

If you want high powered loads from loose powder, I have very good luck with the knight powerstem breach plug and 120gr of 777 and barnes expanders.