I have found that in the Savage 10ML-II, the powder that is the easist to get good accuracy right away is Accurate Arms 5744. Regardless of whether I am using 250gr -300gr bullets, powder charges in the 44-46 grain range work best. These can either be weighed or dipped in the 3.4cc Lee powder dipper. Of course the weighed charges are going to give you a little better accuracy, but only by maybe a 1/4" or so. 5744 works well with Hornady .452 250gr & 300gr XTPs and SST's, the 260gr & 300gr PR Dead Centers, and the 275gr Parker Hyra-con bullets. The sabots of choice is the MMP HPH-12 (long fingered) or the HPH 24 (short fingered). I use both Federal and Winchester 209's.

Out of the 7 Savage ML's that I shoot, I have the following loads. Plus I have a couple of 10ML-II's that I shoot Hi-Performance loads in, that I'd rather not list here, as they are not Savage recommend loads.

1. 45gr 5744, 260gr PR DC, Win. 209
2. 45gr 5744, Hornady .452 300gr XTP, MMP HPH-24 sabot, Fed. 209
3. 45gr 5744, Horandy .452 250gr SST, MMP HPH-24 sabot, Win. 209
4. 45gr 5744, Hornady .452 300gr SST, MMP HPH-12 sabot, Win 209

You can kind of see a pattern here.