Several years back I got a rifle barreled to 257 Ackely which is about the same ballistics wise as a 2506, and my son hunted with it for several years and now a friends' son has hunted with it for several years. In all that time we have used at least a half dozen bullets in it, and we both finally came to the conclusion that we really like the performance of 120 gr bullets of all types over the 100 gr. The 115, 117, and 120gr bullets have a tendency to dig in much deeper than the 100's and we like that. I know several people who hunt with 100 gr bullets, and frankly I think the only reason they do is because they think the extra velocity they get over the heavier bullets is of some great benefit to them in terms of hunting game. I dont think it is myself, but its like a friend of mine says, It dont matter if something is true or if you just believe it to be true. Any bullet in a 2506 will kill deer, start shooting deer with different ones and compare. See what you think. Have fun with it.