Try some Elmer Keith style semi-wadcutter bullets around 300gr. with a Harvester sabot. Elmer shot big animals with the bullet and felt the sharp edge cut veins and arteries rather than pushing them aside like pointed bullets. Since he was a fan of the .45 Colt handgun there are a lot of molds for that style bullet. I am presently considering doing the same thing and I am looking in my mold collection to see if I have a .45 cal bullet like that to try. An additional note: the bullets can be cast from lead somewhat harder than pure lead and possibly even wheelweight lead will give a bullet that will retain the sharp edges longer on tough skin animals.