375H&H... you'll get plenty of penetration to shoot deer and anything else that carries head gear from any angle you want to shoot it at... it's slow enough you don't get a lot of blood shot meat, but fast enough for excellent penetration... if you reload you can go down to 225gr bullets for deer, 250 for moose/elk and 300's for bear... you can buy it almost anywhere large game is hunted... try that with your fancy new super duper magnums... and it'll "Giter Done"...