Busch, if it's the .45 LC that you want, you could go with the .454 Casull!
Most of the time you could use the .45's and when you're out in bear country load it up with the .454's.
IMO that is the best idea , if not a 44mag with heavey cast bullets .
The 45ACP is a poor choice
The proud shooter of a Ruger SRH 454