Shot placement is everything.
What is the most accurate within your effective range and with enough energy to effectively harvest the intended game is all that is required.

For deer, large or dangerous game;
I'll always opt for the heaviest, yet still accurate load for hunting within the loading limits of my given rifle. Recoil does not bother me one bit in a hunting situation. Why? I prefer to deliver as much down energy as possible and I'm only shooting once.

Whatever you feel comfortable shooting and within the limits of your weapon is "Better".

With inlines and optics, I prefer to load heavy enough to the threshold of accuracy pattern at 150-200 yards.

With sidelocks, 100-125 yards is the limit as I'm shooting open sights.