Extreme 1 hit it right on the head. Also cam timing and maintenance can be an issue to consider. With two cam bows the two cams must roll over at exactly the same time, EVERY TIME! This can become a hassle if your strings/cable stretch more than they should. To correct it the string/cable that has stretched needs to have a few twists put in it or should be replaced. With a one cam bow (or a Cam & 1/2; Ram & 1/2; or Bowtech's new Binary cam) timing is no longer a big concern. With a perfectly round idler wheel on the top, the bottom cam has nothing to come out of time with!!
Don't you love this new technology!!