RE: dropping from 125 to 100
Personally, I'd go back to the 100's if they are already tuned, shoot well, and match the point of impact for your 20 yard pin. Then actually shoot them and verify everything is OK before competing.
But, if you're getting decent groups at 20, and the whole match is at 20, it's not a big deal.
I'd definitely get it squared away well before deer season if you hunt.
Get it working right first, and then give yourself a few weeks to practice more with your final setup for the season.
Don't be like some guys who are still tweaking after their 3rd hunt of the year.
I never make any adjustments during the season unless really necessary.