I have had my best accuracy results with both Sierra and Nosler bullets. However, when it comes to shooting anything larger/tougher than deer, I use a Nosler Partition bullet because the front end is soft enough to expand at all ranges, but the rear is made so that it will penetrate at all velocities, even if the front portion explodes! Sierras work well on deer. I have not used them on anything bigger than deer, however.

I have read reports that the new Nosler Accubonds perform almost the same as Nosler's Partition bullets, but have not personally tried them on game yet. I have bought some Accubonds in .375 and 8mm. Will test them the next time I hunt elk.

Hornady bullets also have a good reputation and a lot of people like them. However, I have never gotten as good accuracy from Hornady bullets as from Sierras, Noslers, or even Speers.