RE: Accuracy VS "on game performance"
In my experiance handloading is "all about" whatever my requirement is. If I am loading for hunting, I am going to start with a bullet that is appropriate - a hunting bullet chosen based on a number of criteria. If I am loading for plinking, I will probably choose about the cheapest bullet I can find. For match shooting, accuracy is all I would care about - would probably start with a match bullet.
I generally don't care too much maxing out velocity... as long as the velocity is approp. for what I am doing, that's all I care about. So for hunting I will generally look for a load in the upper 1/3 or so of the load range. For plinking - probably the lower 1/3.