HDW... good choice, either one will work for a truck gun... the 243 will not be as fur friendly as the 22-250, if you're looking to sell fur... either will take out a Mtn Lion easily... lions just aint that bullet proof... if you reload, the 22-250 is very user friendly... have never had any trouble finding a load for a good barrel... I've been messing with the 250 for over 30 years now and it's still one of my favorites... kills everything from groundhogs to deer...