ORIGINAL: gobuffs
How about a Marlin 1895 in 45-70 or 450 Marlin. Mine is 45-70, factory ammo works great on Texas whitetails (and I don't have to track them far) and you can go with handloads or Buffalo Bore for everything up to elephant. It is a nifty little lever gun, you can go with scout scope setup or I have a Leupold 2-7X33 VXII on removeable mounts with iron sights. It has proven to be a little overkill on coyotes but is near perfect for everything else!!!
I couldn't have said it better. I think that throwing Grizzly's in the mix is the difference. I would definitely want the big bore for an animal with the reputation of a grizzly. My .45-70 drops deer like a ton of bricks and I would have confidence hunting grizzly's with it(hot loads of course.) A large .300 caliber magnum would suffice too, but for me it would not be a practical gun to be toating around in the woods for whitetails.
Mr. .45-70