I don't think there is a solid answer to all this. I have seen shots with Muzzleloaders on the hunting shows where the big animals fall down when hit. I personally shot a big cow elk (estimated over 600lbs. as the bare four quarters weighed 475lbs. on the meat hook) and the shot was at 80 yards with 80gr. of Clear Shot with a 348gr. Powerbelt aerotip which turned sideways and went through the center of the heart stopping on the far side ribcage. The elk just walked off about 30 yards and then fell over. You would have almost thought the shot missed. I shot one this year( much smaller) this time with 90gr. of Black Mag'3 and a 300gr. Hornady which I clocked at 1800fps. with the shot at 90 to 100 yards, and only hit one lung and clipped part of the liver and made a second shot when she reached full speed running and she went another 1/4 mile with four big holes in her as all passed completely through. An elk with one lung is almost unstoppable. I don't know what they use to get those immediate drops of big animals. I doubt that with any muzzleloader the answer is hydraulic shock unless I missed something in the calculations.