There is a little difference just not enough to make any difference to me. However my main point is that both calibers are suited to the same kind of hunting. The 280 and 25-06 and even the 7mm08 and 6.5x55 would be in the same group for me. To move up to bigger game for me would requre at least 30 caliber with 180 grain bullets. That said though I am one who believes that the 270 is gun enough for everything in NA except the Grizzly and Polar bear. Of course the 270 has taken them as well.