Not to rain on your parade, but I don't think any caliber is the "magic load". Shot placement is what it's all about. We can all brag about how our .416 anchored that monstorous buck where he stood, but a little .22 rimfire would have done the same thing, with careful shot placement. Once you figure that out, every gun you hunt with is a "magic, drop them in their tracks gun"!!!!!!
My latest magic gun: 7mm RUM pushing a 139gr Hornady SST Interbond @ 3600 fps
Know your enemy.
Big E
Rusty Axe Camp