RE: .223, 22-250, or .243 for yotes
If you don't want to save pelts the .243 ballistics are better. .223 is by far the economical choice. All are capable of a level of accuracy which will place all fault on the shooter. With that said, the .243 will be shot better in a breeze 10 times out of 10.
Iyou DO want pelts. The .223 is very capable out to 300 or so, but the 22-250 will smack 'em alittle farther and alot harder! 22-250 has a bad reputation for barrel life, but only groundhog/high, high, high volume shooters will notice this.