The big problem with the 22 centerfires is that even the 60 grain bullets have a sectional density of only 171. That is not really enough to hang together and penetrate. To much expansion for reliable penetration
Thank you. Well and concisely said. No one is saying that 22 center fire cartridges can't kill deer but their rapid and sometimes explosive expansion on impact make them highly unreliable when it comes to penetration. They were not intended for large game animals and that is why many states have banned their use for deer sized animals.