The big problem with the 22 centerfires is that even the 60 grain bullets have a sectional density of only 171. That is not really enough to hang together and penetrate. To much expansion for reliable penetration. I have taken deer with the 60 grain Partition which because of its constuction, has the ability to perform beyond the average 22 centerfire bullet. I would use a 22 centerfire sparingly with the Barnes X bullet, Trophy Bonded Bearclaw or Nosler partition only.