I use just about any caliber for yotes depends on what i have with me at the time. Ive killed them with the follwing calibers 22LR, 223, 30-30, 308, 30-06,357 magnum, 44 magnum, 38 special, 45acp, 9mm, 410, 20 ga, and 12 ga. Ive found with shotguns steel shot in size T or TT even F works great at close range even better then OO buck in some cases. theres no limits for to big for yotes their a varmint so anything that will make them dead is fine.