I've used Hornady dies quite a bit. In fact, most of what I have are Hornady dies, though I do have an RCBS .22-250 set and several Lee sets. To tell you the truth, I can't tell any difference between any of them at all. It seems like RCBS has a better selection of specialty dies, but not necessarily. If you're asking if you'd be afraid of Hornady dies, I'd say absolutely not.

Good luck