There are reduced loads in the Speer manual for the 100gr, 110gr, 150gr, 165gr bullets using SR4759 powder. The reduced loads for the 180gr and 200 gr bullets use IMR4198 powder.

I'm doing the reduced load thing for my son and his new .270 becuase I didn't want him to ever develop the bad habit of flinching. It really makes a difference and he enjoys shooting these loads.