I have owned and shot a 243 Rem. Mohawk 600 for 30 years. I can't say i haven't missed or wounded a deer or other game animal. I have been able to recover all but a couple over the years. I started with factory ammo and found out that better bullets were available to reloading. The game we shoot deserves our attention to details as we shoot. Don't shoot just because the deer may get away or its huge rack is a must! Make a good clean shot not a do or die shot. I use Barnes X bullets as they penetrate better than any other i have ever shot . I haven't used Sierra bullets in 25 years, found out i didn't like the way they performed![&:]