I use them in a lot of calibers. The first thing I tried them in was my wife's 250-3000 It shot the 100 grain very well and performance on mule deer was very good. I had a little trouble with the early ones in my &mm Rem Mag. However Nostler revamped them a couple times and I have had no more problems. I do not load them as hot as I do regualr bullets and in all calbers they work best for me when kept under 2900 fps and 2700-2800 is even better. Just My Expierence. I love them.