ya'll need to get away from behind those keyboards and get out and shoot something once in a while... instead of reading all these "experts" commentary... the 22-250 is quite adequate for deer in anyones hands that can place a shot where they want it... and has sense enough to know where to place it... the 243 is good for anything in the continental US that grows horn... if the 22 cal's and the 243 aren't what you're confident enough in your abilities to shoot then DO NOT sit and try to bash us that can use them with great results... the way ya'll sit and whine it's evident you wouldn't do as I do and shoot a 375H&H for deer either... eat right up to the hole... don't get the bloodshot meat like you do with the 243... that's just minimal for deer... lolol ya'll need to get out and shoot something other than the breeze...