I have 45's 50's and one 54 cal. If I were to pick one caliber it would have to be the 50cal.There are more accessories out there for the 50's.I shot deer with both the 50 and 54 cal. It lays them low.I'm sure the 45 will do just as well.Any you choose will fill the ticket. I just feel you have more options with a 50 cal.

Ruger Redhawk