My favorite caliber now a days is a 25.06 and thats what i'd use if i ever have the opportunity to hunt Pronghorn. However, even though i've never shot a Pronghorn i have killed countless deer with my 30.06 and a Hornady 130gr Spire point at all ranges and i'm sure it would do no less on pronghorn. That combination shoots flat and i've never lost a deer with it. Sighted in 3" high at 100yds i'm 1 1/2" high at 200, dead on at 250yds and about 6" low at 300. Rest assured the ole 30.06 will do a fine job on Pronghorns as well as about anything else you want to shoot with it.