If you are a young man, and plan on hunting another 30-50 years, why not get a 30-06. It will allow you take anything on our continent (some will argue about certain bears), ammo is available everywhere and in many different types, and you can find any action (auto, bolt, etc.) you might desire. Lots of calibers will suffice if all you are going after are deer; 243, 270, 7mm08 to name just a few. The 280 is a great caliber, but ammo can be scarce in places and manufacturers seem to be chambering their guns less and less for that round. Buy Hey, you can always come up with a valid reason to get another gun.