Thanks for the advice. Very helpful. My loading is pretty standard stuff, hunting and practice. Ruger 77 Mark II in .30-06 Springfield. I'll be happy with sub-MOA at 100. Loading Remington Core Lokt 165 SPs for some of the fairly heavy-bodied deer in NH. Ruger doesn't like lighter loads, and likes IMR 4064 more than IMR 4350 for this load. I'm getting 1" groups with 48.3 grains. I was going to fine-tune in the 47.8 - 48.8 range, and also consider testing some different seats. On the other hand, I may be overthinking this problem.