Alaska Magnum,
For an all around rifle that you describe I would recommend a 375 H&H or one of the 416's.
For all the nitty gritty details of the "416 Wars" go to
www.accuratereloading.com and search the "Big Bores" section for "416, Rigby, and Rem" and you will hear every viewpoint of why one is better than the other, check within the last year --- it is all there.
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Castman,
"....416 and 458 cal bullets all have low BCs, they will all "drop like a mother" past 200 yards...."
You are painting way too wide a generalized swath with your brush!
B.C. of .546 in 416 with a Barnes X 400gr
B.C. of .526 in 458 with a Barnes X 500gr
Those are high, not low B.C.'s.
The 416's in particular, if you can shoot quite flat.
My 416 Rigby with 325gr X bullets at 2900 fps shoots flatter further than either my 30-06 or my 338WinMag and has over 6,000 pounds energy at the muzzle. All is not as it would appear with a superficial glance! (Alaska Magnum, THATS why I chose the Rigby!)