RE: Shooting
I think you get the gest of your original post...NO!
As to which combos will perform best just like a Centrefire, Shotgun or Bow you'll have to find the accuracy combo and the only way is Trial and Error. I would suggest starting around 90 grs loose and moving up by 5's or if you want to shoot pellets try 2x50's = 100gr for powder. Bullets are a different animal, I have seen pretty good results in a variety of inlines(and powders) with the saboted 240gr or 300 gr Hornady XTP's, so you could start their but no gaurantee's.