It seems I am reading more and more reports about Omega's being hard to load even with swabbing. My first question would center on the kind of sabot and bullet combination you're using. What others you have tried, and what you want the rifle to do.
Get yourself some 375 grain Buffalo Bullet SSB sabots. I buy them from Cabela's. I load only 100 grains of Goex FFg but the accuracy is hard to match. I suggested this same load to another Thompson Center user, and learned they dropped a nice cow elk with that load. The bullet expaneded perfect and lodged just under the skin on the other side. I think on a deer it would have passed through.
I shoot a T/C Black Diamond XR and with the SSB's or the T/C line of bullets I get excellent accuracy and loading is not all that ruff. Another thing you might want to look into is some 460 grain No Excuses Conicals. They also shoot excellent....
Good luck. You have a great rifle. Someday I am going to have one just like that exact rifle you have.....