The 30-06 is the best all around cartridge for hunting North America. The only game I wouldn't use it for are the big bears. Other than that it's an acceptable cartridge for critters from varmints to Moose. It's not the best cartridge for any specific situation but it will cover them all. Factory loads are available in the 55 gr. acclerator all the way up to a 220 gr. roundnose. Also ammo can be found just about anywhere.