mistah, I am not sure where you aim and what you usually find your yardages to be on shots. I use 150 gr NBT out of my 7rem mag and have used them out of several other guns as well. As a rib shooter or prefered a quarter through rib and out opposite shoulder on a buck they have never left me sorry for choosing them. I have had one bullet in a lot of deer or lopes not exit and that was purely shooter error hitting flush on the exposed shoulder. Now I will say most of my shots have been over 100 but I have taken a few at close range (well under 100) and while the damage is much larger they had 2 large holes in them. Tracks have been nill to a max of 50 yards and blood trail was "TICK". So if you usually shot 100 + yards and aim for ribs then the NBT might be of interest. I would probably look at 165 -180 grain for the 300 winnie with NBT.

If you aim bone or shoot often under 100 yards then I would stick with a solid bullet like the NP and just up the grain size a bit or have your reloader back off on the heat of the load. You could consider others as well like bonded bullets Accubond(nosler) or Interbond (hornady). A host of others like the TBBC, Speers Grand Slam, A Frame, Failsafes would also work for busting bone at closer ranges in the premium.

Now if you are thinking corelokt I would personally try the Hornady Interlock Spire Points first, they are an excellent deer bullet and I have also found them to be happy in most bores. Again those close ranges norms I'd opt for a bit larger grain size but it is your choice. I know many fancy the corelokt but I have never been to impressed with them especially when driven at higher velocity.

Best of luck in finding the right bullet and get the big one!