The 44 Mag loaded with the proper bullets will cleanly take all Game in North America. To me most of the 50's are big boys toys and more of a novelty than a practical hunting tool. They are to big for conceled carry and not a good option for that anyway. Most 44 Mags are a little big for conceled carry as well ,but its popular so ammo is everywhere and it has plenty of power for hunting. I have had a desire in the past to try almost everything new that comes along. I have however had no desire whatsoever to try the 50 S&W. If the 44 mag won't kill it, give me a rifles.