Think you answered that yourself? The 44 mag can be loaded to almost as powerful as the 50AE. I like the 44mag cause of available ammo, bullets, and reload data. But you are comparing a Auto to a revolver cartridge. I see the 44 rem mag as a hunting caliber. Not really a carry gun or home defense so much. The 50AE is not what I consider a hunting caliber but more a home defense novalty. Sure it could be used as one. But not something I would want to have a carry gun.