I used a .243 for along time on deer in central texas. Our deer are a bit bigger since we feed Protein year around. I have used .223 , 22-250 to kill deer here but i like to have more.

I killed my biggest deer with a .243 95 Gr. Winchester soft points . I did have to put 2 in him.
I LOVE the .243 for the hogs here. Put it right behind the ear and they dont move.