when ever you use one caliber long enough you will run into trouble like Virginia7. i have seen deer with 3 180grain noslers in his heart/lungs and 2 in the guts from a 30-06 run for a good 300 yards when shot that is 900 grains of lead in a deer and it ran. so it isn;t just the caliber, chances are it is going to happen sooner or later no matter what caliber you are shooting.

a kid down the road from me shot a 580 pound bear with a 243. 1 shot ran 20 yards and died.