They are all good calibers and all will handle most N.A. hunting. I too would steer clear of the 7MM Ultra Mag. Not that its not a good caliber but as was already mentioned here the selection of ammo for it is slim and none. If you are going to or already reload and you buy plenty of brass then you would be ok. However if it matters, the future resale or trade in value may not be to good. Remington has a way of jumping ship and leaving cusomers hanging as with thier 5 mm, 8MM Rem Mag and now maybe the 7 Ultra. As long as you are aware of these possibilities, pick whichever you like the feel of. If it were not for other companies jumping on the 260, I think Remington would have dumped it as well. I love Remington rifles but they are strictly bean counters and if the bucks are not there then thier gone.