It depends on how long of a shot you'll be taking with the 454. That round is capable of taking a deer at well over 100yds and if you're comfortable shooting that far off, I'd suggest either a 4X or a variable. I've either owned or still own pistol scopes from Leupold, Nikon and Burris on some T/C handcannons and they all held up well. Nothing against Leupold or Burris, but I've got a couple of Nikon 1.5-5X variables and absolutely love them!! They're very bright, clear and cost about 100 bucks less than the variable from Leupold. The Leupie does have a higher magnification(8X), but I don't think you'll need that much with the 454. This is just my opinion on what I'd do. Good luck and congrats on the new toy.