I shoot a .44 Super Redhawk, without a muzzle brake. The S&W .500 witha muzzle brake was not too much more than the .44. Nothing as it has been written up to be!
If you are talking recoil, now that depends. I shot 4 of the 5- 270 grain Corbon rounds that the seller gave me with the pistol. Those compared to shooting a .44 mag. More muzzle blast, though. My own loads with 350 grain jacketed HPs had some what more recoil, but not unpleasant. My maximum charges under 440 grain HCGC projectiles are very unpleasant to shoot. Very.