STAY AWAY FROM THE BEDS.
I repeat stay away from the beds!
If you've got a good run that leads to a bedding area hunt that. I would prefer to hunt a travel zone 100% to bedding areas and here's why. If you get busted on a travel route the deer will untimately continue to there destination but of you get busted in the bed room your gig is up. The deer will vacate this area. IMO it's the same case with a food source. Hunt them in the travel routes not over the food.
Now repeate after me, I will not hunt the beds
Also I noticed your post said main run. If you're hunting bucks look for smaller secondary runs. Buck will travel buck routes which ofter don't resemble a deer run. In my experience if you've found a cow path it's likely a doe run. Buck often parrell these "doe runs" just inside heavier cover or down wind (prevailing winds) of the primary runs.