In answer to your question Yup! Major differences in factory loads and every gun out there will like a certain load and perform well the trick is to find what your gun likes and stay with it. Same if you are reloading you have to find what will perform best in your gun, as a lot of people say work up a load. I hope this helped some I dont have any technical stats but I am sure you will be getting the experts soon to answer yoyr question.