I have to go with the 30-06 like josh sorensen. The 30-06 would be the all around better caliber for a single shot, if you dont mind the kick even though its not that bad i dont think.The 06 has plenty of power to shoot the smaller grain bullets and the lager ones.
I've got a neighbor who thinks all his guns are better then mine too.He has a 308 and i have an 06.I get tired of hearing how much his caliber is better then mine[:@]