RE: What you believe is commonly overlooked when tuning or troubleshooting.
Ditto on the hand placement and torque. IMO, proper and consistent hand placement and avoiding or limiting torque is in the top 5 of what many shooters take for granted, or do not know how important hand placement and torque avoidance is.
Centering a rest is up there too. I wonder how many shooters don't take the time to center a rest, or believe that a perfectly centered rest is a one size fits all adjustment. On one of my compounds, after a week of shooting frustration I determined that I have to set my rest slightly off center, to the right (window). I concluded that the cut of the riser, the grip, and my anchor on the particular bow, for some unknown reason will not let me perfectly center the rest and get good accuracy (flight).