NVMIKE

The 22-250 has a much higher powder capacity, therefore higher velocity and therefore longer range. You can also shot heavier bullets better w/ the 22-250, which is where the real range advantage lies, because the heavier bullets are more stable at longer ranges(a 35 grain bullet will drift and lose velocity faster than a 100grainer will). 223 is DIRT cheap to shoot, and I have one for that reason coupled w/ the fact that w/ a 22-250 you use almost as much powder as the 6mm,243,7mm-08, but really dont have a versitile rifle. With one of these others you can use small bullets for varmits and use heavier bullets for deer, antelope, ect... So take your pick. The 22-250 is nearly the perfect varmit rifle, but not much use for anything else. I own 2 - 223's and several 6mms.