The 22-250 is a little faster , but the range thing mute. The only way to teel is the gun /load/shooter ability to hit a target .The fastes bullet is nogood if the shooter can't hit the target . example I varmit hunt with a tricked out AR-15 that is not as accurate at 200 yds as my buddys 243 but at 600 yds his gun/load shoots poorly but my 75gr Hornady A-max bullets just keep hiting chucks