I do not have a .450 but I do have a 45/70. There is little difference between them in the higher pressure loads of the 45/70 , the 45/70 is more versatile then the .450 and easrier to find loads for . If you reload the 45/70 will actully out do the .450. Check out the buffalo bore or garrett web site for factory loads (only if you have a rifle that will handle them ) I can tell you they are awesome. I have taken one whitetail with mine and it was very affective. But that was with a winchester 305 gr.